Clicking on a desktop shortcut and it will not load; also programs will not start from the start menu. Can only run programs that have a keyboard shortcut or run in safe mode.O/S is Windows 2000.
Any help would be greatly appreciated!
Rustanger.

read another post with similar problem so here is the hijack this log.
Logfile of HijackThis v1.97.7
Scan saved at 12:30:24 PM, on 5/19/2004
Platform: Windows 2000 SP4 (WinNT 5.00.2195)
MSIE: Internet Explorer v6.00 SP1 (6.00.2800.1106)

Running processes:
C:\WINNT\System32\smss.exe
C:\WINNT\system32\winlogon.exe
C:\WINNT\system32\services.exe
C:\WINNT\system32\lsass.exe
C:\WINNT\system32\svchost.exe
C:\WINNT\System32\WBEM\WinMgmt.exe
C:\WINNT\system32\userinit.exe
C:\WINNT\Explorer.EXE
C:\Temp\HJT\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://red.clientapps.yahoo.com/cust...ch/search.html
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://red.clientapps.yahoo.com/cust.../www.yahoo.com
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://mail.hpedsb.on.ca:90/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://red.clientapps.yahoo.com/cust...//my.yahoo.com
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Bar = http://red.clientapps.yahoo.com/cust...ch/search.html
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://red.clientapps.yahoo.com/cust.../www.yahoo.com
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://red.clientapps.yahoo.com/cust...//my.yahoo.com
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://red.clientapps.yahoo.com/cust.../www.yahoo.com
R1 - HKCU\Software\Microsoft\Internet Explorer\SearchURL,(Default) = http://red.clientapps.yahoo.com/cust.../www.yahoo.com
O2 - BHO: (no name) - {02478D38-C3F9-4efb-9B51-7695ECA05670} - C:\Program Files\Yahoo!\Companion\Installs\cpn\ycomp5_3_12_0.dll
O2 - BHO: (no name) - {53707962-6F74-2D53-2644-206D7942484F} - C:\Program Files\Spybot - Search & Destroy\SDHelper.dll
O3 - Toolbar: &Radio - {8E718888-423F-11D2-876E-00A0C9082467} - C:\WINNT\System32\msdxm.ocx
O3 - Toolbar: &Yahoo! Companion - {EF99BD32-C1FB-11D2-892F-0090271D4F88} - C:\Program Files\Yahoo!\Companion\Installs\cpn\ycomp5_3_12_0.dll
O4 - HKLM\..\Run: [Synchronization Manager] mobsync.exe /logon
O4 - HKLM\..\Run: [vptray] C:\Program Files\NavNT\vptray.exe
O4 - HKLM\..\Run: [CyberArmorHelper] C:\Program Files\CyberArmor\pcshelp.exe -check
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - HKLM\..\Run: [EM_EXEC] C:\PROGRA~1\Logitech\MOUSEW~1\SYSTEM\EM_EXEC.EXE
O4 - HKLM\..\Run: [IntelliType] "C:\Program Files\Microsoft Hardware\Keyboard\type32.exe"
O4 - HKLM\..\Run: [LogitechVideoRepair] C:\Program Files\Logitech\Video\ISStart.exe
O4 - HKLM\..\Run: [LogitechVideoTray] C:\Program Files\Logitech\Video\LogiTray.exe
O4 - HKLM\..\Run: [LogitechGalleryRepair] C:\Program Files\Logitech\Video\ISStart.exe
O4 - HKLM\..\Run: [Motive SmartBridge] C:\PROGRA~1\NETASS~1\SMARTB~1\MotiveSB.exe
O4 - HKLM\..\Run: [IPInSightLAN 01] "C:\Program Files\Visual Networks\Visual IP InSight\Sympatico Consumer\IPClient.exe" -l
O4 - HKLM\..\Run: [IPInSightMonitor 01] "C:\Program Files\Visual Networks\Visual IP InSight\Sympatico Consumer\IPMon32.exe"
O4 - HKCU\..\Run: [LDM] C:\Program Files\Desktop Messenger\8876480\Program\BackWeb-8876480.exe
O4 - HKCU\..\Run: [Yahoo! Pager] C:\Program Files\Yahoo!\Messenger\ypager.exe -quiet
O4 - Global Startup: Event Reminder.lnk = C:\Program Files\Broderbund\PrintMaster\PMREMIND.EXE
O4 - Global Startup: Logitech Desktop Messenger.lnk = C:\Program Files\Desktop Messenger\8876480\Program\LDMConf.exe
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Microsoft Office\Office10\OSA.EXE
O4 - Global Startup: NetAssistant.lnk = C:\Program Files\NetAssistant\bin\matcli.exe
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office10\EXCEL.EXE/3000
O8 - Extra context menu item: Yahoo! Dictionary - file:///C:\Program Files\Yahoo!\Common/ycdict.htm
O8 - Extra context menu item: Yahoo! Search - file:///C:\Program Files\Yahoo!\Common/ycsrch.htm
O9 - Extra button: Messenger (HKLM)
O9 - Extra 'Tools' menuitem: Yahoo! Messenger (HKLM)
O12 - Plugin for .swf: C:\netscape\Program\PLUGINS\npswf32.dll
O16 - DPF: {166B1BCA-3F9C-11CF-8075-444553540000} (Shockwave ActiveX Control) - http://download.macromedia.com/pub/s...ctor/swdir.cab
O16 - DPF: {30528230-99F7-4BB4-88D8-FA1D4F56A2AB} (YInstStarter Class) - http://download.yahoo.com/dl/installs/yinst0401.cab
O16 - DPF: {597C45C2-2D39-11D5-8D53-0050048383FE} (OPUCatalog Class) - http://office.microsoft.com/productu...ntent/opuc.cab
O16 - DPF: {74D05D43-3236-11D4-BDCD-00C04F9A3B61} (HouseCall Control) - http://a840.g.akamai.net/7/840/537/2...ll/xscan53.cab
O16 - DPF: {9F1C11AA-197B-4942-BA54-47A8489BB47F} (Update Class) - http://v4.windowsupdate.microsoft.co...862.8283912037
O16 - DPF: {A17E30C4-A9BA-11D4-8673-60DB54C10000} (YahooYMailTo Class) - http://us.dl1.yimg.com/download.yaho...ymmapi_416.dll
O16 - DPF: {C2FCEF52-ACE9-11D3-BEBD-00105AA9B6AE} (Symantec RuFSI Registry Information Class) - http://security.symantec.com/sscv6/S.../bin/cabsa.cab
O16 - DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) - http://download.macromedia.com/pub/s...sh/swflash.cab
O17 - HKLM\System\CCS\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: Domain = sympatico.ca
O17 - HKLM\System\CCS\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: NameServer = 192.168.2.1
O17 - HKLM\System\CS1\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: Domain = sympatico.ca
O17 - HKLM\System\CS1\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: NameServer = 192.168.2.1
O17 - HKLM\System\CS2\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: Domain = sympatico.ca
O17 - HKLM\System\CS2\Services\Tcpip\..\{06D6686A-0ECC-42AC-AF97-44A5F1EFB0EF}: NameServer = 192.168.2.1