Well, I managed to at least confuse the program for awhile, but I know I haven't gotten rid of it.
I downloaded that SpyBot: Seek and Destroy program, and it's great...I'll have to send a donation to the creator for that one....It seems to be worth it. It did find a few items on my computer that Ad-Aware missed, though, unfortunately, it did not find the Isle.exe program I wanted it to find.
I'll still have to find myself another Virus Scanner, as Mcafee is not allowing me to download updates anymore anyways. I'll give that free one a try, and then look at purchasing Norton.
The file was definitely a smart one. Just creating a new, empty file named isle.exe didn't fix the problem. At startup, I'd get the message that Isle.exe is not a valid Win32 application, and then I'd look to find out that my fake had been replaced by the same, aggravating program. Finally, I created a fake in DOS, and made it a hidden, archive, read-only file as was suggested. This has managed to confuse the program enough that things are working again. I can even connect to my mail and FTP servers again.
Thanks again for all your suggestions...and I hope that nobody else manages to pick up this file; It has caused me over a week and a half of aggravation.