Is there a way to overlay graphics in Python? I'm looking for functionality similar to X-fire. That is, I want to be able to press a set of keys in a game and a GUI screen with some options (possibly a shell script) that doesn't cover up the game should come up without the need to alt+tab.

I would like to do this because the games I'm playing respond very negatively to alt+tabbing but X-Fire works fine in them. I've looked everywhere for a solution but have yet to find one.