//use System.Web.UI.HtmlControls.HtmlInputFile >> filSelectFile
string nameOfFile = filSelectFile.Value;//Get selected file
//Get actual file name
int last = nameOfFile.LastIndexOf("\\");
nameOfFile = nameOfFile.Substring(last + 1);
//Saving location
//this must be virtual folder of your web server
string uploadFolder = ConfigurationSettings.AppSettings["FileUploadFolder"];
nameOfFile = uploadFolder +"\\" + nameOfFile;
//Upload the file
filSelectFile.PostedFile.SaveAs(nameOfFile);