I'm sorry for abandoning this thread - the user decided her university's IT department knew better than I did and reformatted the PC without checking with me first. Of course, they didn't back up her data either. Oh well, her loss.

She did manage, however, to infect someone else and I have her laptop with me right now. Same circumstances as before, including Windows Vista as the OS. I don't want to start a new thread for (seemingly) the same issue.

This time, however, I cannot run Malwarebytes in Normal or in Safe Mode. It installs just fine, but it doesn't launch - no error message. No process shows up in the Task Manager. No entries in the Event Log.

HiJackThis will not install in Normal or Safe Mode. In normal, Vista reports that the application did not install properly. In Safe Mode, nothing happens when running the install. It does, however, generate an Event Log entry. "Faulting application HJTInstall.exe, version 1.0.0.1, time stamp 0x46683992, faulting module HJTInstall.exe, version 1.0.0.1, time stamp 0x46683992, exception code 0x80000003, fault offset 0x001fac9, process id 0x81c, application start time 0x01c97cef6411f325."

I've had a lot of experiences with nasty-ware (I work in an IT Department so I see A LOT of stuff), but this has me stumped.