Well the first thing I would do If I saw this happening is to check the laser on the bottom of the mouse was clean, check to see how the batteries were (If Wireless and Laser) Check to see if the...

What do you mean by Hijacked? Like it moves by itself?

It might not be related to the HDD itself...

Try unplugging every connection in the Computer and put them all back in their correct positions...

In my Computer Engineering class this solution...

Have you been updating your computer frquently??? with microsoft updates??