I'm afraid i've never done that, so i wouldnt know.
Plug it in, and find out.
Either your BIOS will pick it up.
Or the OS will pick it up as removable storage.

USB drives are designed for compatibility and plug n play.
Is the drive you're referrring to a USB drive or an IDE drive that you're building your own case for?

Nonetheless, plugging an IDE HDD...