I've installed a few software quite some time ago and the icons aren't working correctly. I tried solving it with Tuneup and CCleaner but it can't solve it either.

First, when I open the file, they did not get the file type and ask me what program I want to open it with.
Second, the icons aren't showing correctly.
Third, when I Save(not Save As) a file in Lightwave, they ask me what I want to save it as and whether I want to replace it. This didn't happen in XP.

This is how it looks like:
http://i63.servimg.com/u/f63/12/53/83/84/illust10.jpg
http://i63.servimg.com/u/f63/12/53/83/84/photos10.jpg
http://i63.servimg.com/u/f63/12/53/83/84/reader10.jpg
http://i63.servimg.com/u/f63/12/53/83/84/layout10.jpg
http://i63.servimg.com/u/f63/12/53/83/84/modele10.jpg

By right the icon should be the only thing showing, not the white page. As for Adobe Reader, it is suppose to show the preview of the first page image.

If this windows install has been active for over a year I think it's time for a windows reinstall. You could try restoring to a previous system restore point

Actually I installed them right after I installed Vista.