My computer is completely locked up. I can't even get in Safe Mode. What can I do to bypass this, so I can delete it?

If nothing works and you are completely locked out, try Trinity Rescue Kit

Best Luck
pp

try MalwareBytes Anti-Malware download & update the lastest version of MalwareBytes Anti-Malware and boot your pc to safe mode and scan it with MalwareBytes Anti-Malware.

I tried that, but I can't boot in safe mode and when I plugged in the usb stick with malware's on it, Windows Police Pro attached itself to it and it wouldn't open. Any other ideas? I can't seem to bypass it.

-- What is your OS?
-- What are you able to do on the ill computer?

PP

With WPP you should be able to Ctrl/Alt/Del and end process on the WPP app. On my system it stoped for about 5-10 seconds before loading itself back up but this should be enough time to double click Mb-Am or your a/v software. Once you get the antivirus software up even if Police Pro pops up you will still be able to run a scan, the scan should get rid of the malware app for the time being giving you the ability to take the further steps to completely remove the malwares rootkits.