I am a tech for a school district. We are having issues with users logging in and getting this error: userinit.exe - application error The application failed to initialize properly. Click on ok to terminate the application.

Once they click on Ok their Icons do not appear, some get text but no icon and some get nothing at all on their desktops. If you try to log off with c-a-d then it brings up the box but doesn't let you use any of the options on the screen because the icons aren't there.

We have tried several fixes, one of them being ComboFix, it worked on a couple of the computers but it is not a fix all on all of them district wide. We have also wiped the computers and reloaded them from scratch and as soon as you get through and log in they get the error again. HELP....I need suggestions.

Sounds like a virus.
Combofix is usually run to address malware/virus issues.

I suggest you start a new thread here; http://www.daniweb.com/forums/forum64.html