Well firsty, sometimes when my computer gets unexpected restarted or the power goes out (whenever the computer is not shut down really) when I go to turn it back on my optical mouse doesn't work. So therefore It cannot trigger my moniter on. Which is never been a HUGE problem because it starts working again after a couple of hours.

But now it wont work at all! No matter what mouse I try in the USB ports, it doesn't work and the red optical light doesn't come on. So I can't use my computer! Please help me!!

maybe the motherboard/ USB ports are malfunctioning. Contact your PC manufacturer if they can help.

Well last year a friend did mess around with the motherboard and swap some things around. Thats probably exactly what it is. I'll take it to a computer guy tomorrow! Thankyou!

No problem.