hello....
as i m building a job site. i am getting resume for the applicants through,but now i want to send them auto generate mail. i.e; when they send me mail and after i get the mail. my system should automatically send the mail to them that thank you for sending mail. etc to them.

so can this be done in ASP.NET

ASP.NET is not a mail server. Your users are sending email to a mail server, not to an ASP.NET application. If you want to send an email programmatically when a user fills out a form or clicks a link to your ASP.NET application, you can do this of course. Simply search for [search]ASP.NET email[/search] for plenty of examples.

If you want your mail server to send an auto-response, read the documentation for your mail server.