As far as I can tell, it won't work. Rather, Sound Blaster provides separate made for mac soundcards. However, the sound cards that ship with Apple are pretty good - I would be confident they would work with 5.1 speakers.
CDW indicates the following is mac compatible. You may wish to double check just in case: http://www.cdw.com/shop/products/default.aspx?EDC=485738
cscgal
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