Do you have any folders (junk mail, deleted mail, sent mail) that are simply enormous? Perhaps extensive mail rules are slowing it down (does Mail even support this feature?) I use Entourage myself, and I'm quite happy with it.
Did you do an upgrade from Panther to Tiger or a clean reinstall? The mail app in Tiger has some significant changes, and it might just be that the app didn't upgrade cleanly? I always have incredible problems doing OS upgrades - everything constantly takes minutes to open and eventually freezes on me.

That's why I always do clean reinstalls.
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