If you're using ATI...you can run the card in Dual Head mode. Install the ATI proprietary driver and control panel, go into the control panel, enable dual screen, extend desktop horizontally, logout and log back in. You're set.
There also a thread about setting it up at linux questions:
http://www.linuxquestions.org/questi...ad.php?t=40125
If you aren't using ATI, It's possible but difficult...
http://www.tldp.org/HOWTO/Xinerama-HOWTO/
There are a couple of caveats to it as well...such as different resolutions on different monitors, etc. If you're looking for a good window manager that is Xinerama capable..try enlightenment.