First move Hijack This to a permanant folder on your computer (NOT the Desktop, Temp or Temporary Internet Files)
Close all browser windows, Rerun Hijack This and tick the following:
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://red.clientapps.yahoo.com/cus...rch/search.html
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://red.clientapps.yahoo.com/cus...://my.yahoo.com
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Bar = http://red.clientapps.yahoo.com/cus...rch/search.html
R1 - HKCU\Software\Microsoft\Internet Explorer\SearchURL,(Default) = http://red.clientapps.yahoo.com/cus...//www.yahoo.com
R1 - HKCU\Software\Microsoft\Internet Connection Wizard,Shellnext = "C:\Program Files\Outlook Express\msimn.exe"
O2 - BHO: (no name) - {BEB133E5-FD72-43b7-8AFF-681831CC72D9} - C:\WINDOWS\wiesasp2.dll
O3 - Toolbar: (no name) - {E0E899AB-F487-11D5-8D29-0050BA6940E3} - (no file)
O4 - Startup: Microsoft Find Fast.lnk = C:\Program Files\Microsoft Office\Office\FINDFAST.EXE
O4 - Startup: Office Startup.lnk = C:\Program Files\Microsoft Office\Office\OSA.EXE
O16 - DPF: {03F998B2-0E00-11D3-A498-00104B6EB52E} (MetaStreamCtl Class) - https://components.viewpoint.com/MT...s5/b5_flag.html
O16 - DPF: {11111111-1111-1111-1111-111111111111} - http://207.246.124.105/cabs/ROOSTRS3002/TPS108.cab
O16 - DPF: {1C955F3B-5B32-4393-A05D-24B4970CD2A1} (Video Class) - http://stream1000.babenet.com/cabs/videox.cab
O16 - DPF: {41F17733-B041-4099-A042-B518BB6A408C} - http://a1540.g.akamai.net/7/1540/52...meInstaller.exe
O16 - DPF: {56336BCB-3D8A-11D6-A00B-0050DA18DE71} (RdxIE Class) - http://207.188.7.150/0478639e68608c...ip/RdxIE601.cab
O16 - DPF: {5D11F7A5-DB3D-458B-80DF-08EFC77C4F39} (NetOnCourse MILive Participant Control(MR)) - http://62.219.1.103/events/bin/medi....2.3/MILive.cab
O16 - DPF: {75D1F3B2-2A21-11D7-97B9-0010DC2A6243} (SecureLogin.SecureControl) - http://secure2.comned.com/signuptem...iveSecurity.cab
O16 - DPF: {E7DBFB6C-113A-47CF-B278-F5C6AF4DE1BD} - http://download.abacast.com/download/files/abasetup.cab
Click FIX CHECKED.
Reboot.
Also, you have three messengers starting on boot - I left them alone, but don't recommend you allowing them to autorun - instead get Trillian, remove all three of them, and start it yourself ;)