This could be the cause of your problems
O4 - HKLM\..\Run: [TB_setup] C:\DOCUME~1\Melissa\LOCALS~1\Temp\tb_setup.exe /dcheck
And this
O4 - HKCU\..\Run: [Terminate Popup] C:\Program Files\Free-Popup-Killer\fpuk.exe
http://www.pestpatrol.com/pestinfo/f/free_popup_killer.asp
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Go to add and remove programs and uninstall the Free pop up killer program .
Then
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Then put hijackthis.exe in its own folder on the c:\ drive
Close all brower windows and run hijack again and fix the following .
O4 - HKLM\..\Run: [TB_setup] C:\DOCUME~1\Melissa\LOCALS~1\Temp\tb_setup.exe /dcheck
O4 - HKCU\..\Run: [Terminate Popup] C:\Program Files\Free-Popup-Killer\fpuk.exe.
Then go to C:\DOCUME~1\Melissa\LOCALS~1\Temp\,and delete the content of the temp folder .
Reboot and Run hijack again and post a new log