Go here to TrendMicro for an on-line scan & set it to autoclean for you. When it completes, post back the full filename of any files that cannot be cleaned or deleted.
Try this scan at Panda as well.
The scan here does not require an active X install, but uses java instead.
http://fr.trendmicro-europe.com/consumer/products/housecall_launch.php
Clear out your Temporary internet files and other temp files.
Go to Start > Settings > Control Panel >Internet Options.
Under the General tab click the Delete temporary internet files,
delete all Offline content as well. Clear out Cookies.
Also, go to Start > Find/search > Files or folders > in the named box, type: *.tmp and choose Edit > select all -> File > delete.
Empty/delete the entire contents of the C:\Windows\temp folder and C:\temp folder, if you have one. (Contents but not the folder itself.)
This one too if Win2K or XP.
C:\Documents and Settings\username\Local Settings\Temp\
In order to view these files you may have to select 'show hidden files/folders.' Instructions on how to here.
Empty the Recycle Bin.
Download HijackThis from here & it will install into it's own, permanent folder.
If you have anything disabled in MsConfig, please re-enable it/them and reboot.
Start HJT & press the "Do a system scan and save a log file" button. When the scan is finished a window will pop up giving you the option of where to save it. Save it to desktop where it is easy to access. Open the log file and copy the entire contents of the file & paste it into the body of your post. DO NOT FIX ANYTHING YET. Most of what is there is necessary for the running of your system.