Neitz, check in the root of each affected drive to see if there is a file called autoruns.inf: if so, delete it. Then...
==Please download Malwarebytes' Anti-Malware
from: http://www.majorgeeks.com/Malwarebytes_Anti-Malware_d5756.html
or: http://www.besttechie.net/tools/mbam-setup.exe
=Dclick that file, mbam-setup.exe, to install the application,
-ensure that it is set to update and start, else start it via the icon, and UPDATE it.
Select "Perform QUICK Scan", then click Scan; the application will guide you through the remaining steps.
ENSURE that EVERYTHING found has a CHECKMARK against it, then click Remove Selected.
If malware has been found [and removed] MBAM will automatically produce a log for you when it completes... do not click the Save Logfile button.
Examine the log: if some files are listed as Delete on Reboot then restart your machine before continuing.
Copy and post that log [it is also saved under Logs tab in MBAM].
gerbil
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Aw... please don't run registry cleaners. They just don't do anything worthwhile. If you really want to speed up registry access then remove spaces and defragment it - sysinternals have a pgm for doing that latter.
gerbil
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An example would be C:\ autorun.inf
Just use Explorer, expand each drive [partition] if it exists. If not, just run MBAM. These files are usually found in software cds to automatically start the installation processs when you insert the cd, saves you hunting for setup.exe or whatever. But you can write all sorts of instructions into them. Naughty ones.
gerbil
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That's good, neitz, so now we know the problem. But something put that file there, and it is likely still in your machine. I do strongly suggest yur run MBAM as above. Post the log.
gerbil
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I did tell you that some malware inserted those autorun.inf files; just deleting them may not cure the problem. And that you should run MBAM as a next step.
gerbil
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So these files, autorun.inf and backupuser.exe, are not being recreated now? That's fine then, Neitz.
gerbil
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You are going to have to wipe your flashdrive and format it. Remove it. Then try this:
==Download this file to your DESKTOP: http://download.bleepingcomputer.com/sUBs/ComboFix.exe
.....or this file: http://subs.geekstogo.com/ComboFix.exe
-IMPORTANT! : disconnect from the web, turn off your Antivirus, Antispyware and Firewall for the duration of this scan. Don't forget to reset them before you go back on the web!
- to run it dclick the Combofix.exe icon and follow the prompts to start it. When finished, it will produce a log, C:\Combofix.txt - post that log in your next reply.
A word of caution - do not touch your mouse/keyboard until the scan has completed. The scan will temporarily disable your desktop, and if interrupted may leave your desktop disabled. If this occurs reboot to restore the desktop.
gerbil
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