Important: Create a folder on the C: drive called C:\HJT.
You can do this by going to My Computer (Windows key+e) then double click on C: then right click and select New then Folder and name it HJT.
Unzip HijackThis into this folder. When you run HijackThis from this folder and have it "Fixed checked" it will create a backup file of modifications to use if restore is necessary.
Have Hijack This fix the following by placing a check in the appropriate boxes and selecting fix checked. Make sure all browser and all Windows Explorer windows are closed before fixing.
O2 - BHO: My Search BHO - {014DA6C1-189F-421a-88CD-07CFE51CFF10} - C:\Program Files\MySearch\bar\1.bin\S4BAR.DL
O3 - Toolbar: My &Search Bar - {014DA6C9-189F-421a-88CD-07CFE51CFF10} - C:\Program Files\MySearch\bar\1.bin\S4BAR.DLL
fis this rescource hog,not needed in startup
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Microsoft Office\Office\OSA9.EXE
Reboot and post a new log .
also would be good to know what kind of problems you are having .