Download CWShredder from here & run it. Select the fix button & it will get rid of everything related to CoolWebSearch that is stored in it's database. Close ALL windows, including IE, before running CWShredder. Reboot.
To help prevent this from happening again, install the patches for the vulnerabilities that this hijacker exploits by going here for your critical updates.
Unzip HJT into it's own permanent folder before doing anything in order for it to create backups. (Not a temporary folder or directly on the desktop & not directly on your hard drive). Close all (browser) windows & rescan with hijackthis. When the scan is finished place a check in the box to the left of the following entries & click 'fix checked' :
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://srch-qus8.hpwis.com/
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = res://mshp.dll/sp.html#22776
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://srch-qus8.hpwis.com/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = res://mshp.dll/index.html#22776
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Bar = http://srch-qus8.hpwis.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = res://mshp.dll/sp.html#22776
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = res://mshp.dll/index.html#22776
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = res://mshp.dll/sp.html#22776
O2 - BHO: (no name) - {2E9CAFF6-30C7-4208-8807-E79D4EC6F806} - C:\Program Files\Submit\submithook.dll
O2 - BHO: (no name) - {FD9BC004-8331-4457-B830-4759FF704C22} - C:\Documents and Settings\Owner\Application Data\ieyg\msiesh.dll
O2 - BHO: (no name) - {FDD3B846-8D59-4ffb-8758-209B6AD74ACC} - (no file)
O4 - HKLM\..\Run: [DSS] C:\WINDOWS\BBSTORE\DSS\DSSAGENT.EXE
Reboot & delete this folder: C:\Program Files\Submit<<<<
Delete this file: C:\Documents and Settings\Owner\Application Data\ieyg<<<<
Go to the following site for instructions on how to remove DSSAGENT from your registry.
http://cexx.org/startup.htm#registry
Reboot again then post a new log plz.