Which OS are you using and do you have administrative privaliges on the computer?

Ad ware is a growing problem. I run several removal tools and about every 3rd boot I still get the "bargain buddy" puppy in my tray. I'm behind a router, I use zone alarm, I run ad aware, spybot s&d, BHO demon, hijack this and norton 2005 (which recognizes a lot of ad ware) and I have a shortcut to regedit on my desktop.

The only thing I have found that works is using Firefox as a browser instead of the vaunerable IE.

Go to this thread and follow all the recommendations, CWShredder in particular:
http://daniweb.com/techtalkforums/thread5690.html

Note: if you end up needing to post a HijackThis log (explained in that thread), please post it in the Security forum.