The file is about 300 MB. Just tried everything with the same results on a different computer.

No luck.

I'm puzzled.

Well, depending on how much data is on it, there is always the copy everything off, format and copy everything back...

The chkdsk thing should work, but it's strange that it is not letting you.

Yeah, I think the reason chkdsk isn't working on reboot is because when the computer reboots it does not recognize the external hard drive until it is unplugged and plugged back in (though I'm not sure why.)

It's more of an annoyance than anything (especially since I can't find a solution) and isn't worth taking the time to copy everything off of it (it's a 111 GB hard drive and only has about 5 GB of free space.)

I'll keep searching for a solution and if anyone has any other ideas I am all ears!

go to mycomputer ,right click on desired drive and chose properties ,then tools , error checking ,click on fix now check the empty boxes ,it should not prompt to restart computer ,if does just check off one option at a time

Took a few hours to run but this worked! The file is gone. Thanks so much for your help!

your welcome ,good luck

If you have any anti-virus eg.avg,avira or etc, just scan your
USB drive with that anti-virus and see if this file is infected or not.
If it is infected then move it to the quarantine.
If the file is not infected, then make sure you make a backup of all
the data from this usb drive to your system and format this usb drive.

After performing this , write back to this thread.

Hi friends ,

My openion
1.Format the drive after copying your important data to another harddrive or pendrive .
2. Goto command prompt then use e:\del /f /q file_name.extension

Just try this