The registry is so large and encompassing that if you were to trim everything that you didn't need from it, of course the registry would be smaller, but you would sacrifice your sanity and well-being trying to clean it out. There's no reason to be so anally-retentive about a few bytes in your registry.
Download regclean from here...you'll see more results with this than you will manually spelunking the registry I'm sure.
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