Sounds as though you have either a driver issue, or device conflict issue with that particular install of windows, which i will assume is XP!
Have a check in 'device manager', and see if there are any yellow exclamation marks or red crosses next to the device in question!
Having used Vista since its early development, i forget the exact path in XP, but i think you can access device manager from start>control panel>administrative tools>computer management, open DM from the left tree pane and then click on the little plus (+) signs next to 'keyboard' and 'mice and other pointing devices'.
If you dont see any colored symbols, right click the listed devices in question and select 'properties' then the 'driver' tab at the top!
From here you should see the currently installed driver version, date and supplier.
You can also update( which is the option you should choose), roll back and uninstall the current drivers!
Installing the current driver versions for your devices is not a bad idea, and these can be usually obtained from the device manufacturers website if windows doesnt find them on the update!
Good Luck