It doesn't always wpork like a charm - but there's a methodology that begins with the HJT log and either you decoding it and acting accordingly, or you post in the Spyware section and let the experts guide you through.
The other approach is detailed in my famous post:
http://www.daniweb.com/forums/thread88342.html
which you can do all by yourself but has to be absolutely thorough.
Good luck.
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