Yeah i must agree with Suspishio that it can make a big difference in performnance if you have, say, a 5200 rpm drive compared to a 7200 rpm drive. This is not very noticable usually, but if you are doing a lot of disk intensive operations (e.g logging, hence why servers have high speed disks) or swapping, then it can make a difference (this is why if you dont have much ram and therefore swap a lot on a laptop it always seems significantly slower to the user than the same scenario on a desktop, which would have a faster drive).
My main tips:
reduce startup programs. if its an OEM installed system it will come bundled with so much crap. You will notice that vista runs 2-3 times faster on a clean end-user install, due to this.
Also, reduce unnecessary effects and buy more ram (2gb is what i recommend - don't need more than 2.5 or 3 unless you are into heavy video editing or a gamer) and most importantly, get a decent video card. You will notice vista will be much faster if you upgrade from, say a crappy intel integrated solution, to a low end Nvidia card (something like an 8400, which can be picked up for very cheap) will provide a speed boost.
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