no problem Tom.
without actually looking at your PC its very hard to diagnose what the exact problem could be. If the noise appears to be loudest at the top of the machine it could lead to one of two things, one of which i've already said before in it being the cd drive. the other option here is probably the Power supply unit. it is quite possible that the power supply fan has come loose or got a chip in it somehow.
the only way to tell whether its the cd drive or the PSU is to do the following.
1. power down the machine and unplug the cables. ensure the wall outlet is off
2. open up your machine
3. locate the bay where your cd drive is located
4. gently but firmly remove both the IDE and power cables
5. power up the machine again (PCs dont need a cd drive to be able to kick in)
If the problem is still occurring after this reboot without the CD drive connected then i would most certainly rule out the cd drive as being at fault and concentrate on the possibility of the power supply unit.
If you dont feel confident in yourself in carrying out the above proceedure please take it to a repairs store.