Well, some old, old legacy 16-Bit apps won't run. I'm talking real mode DOS apps here. And that's because WIndows ME onward do not include legacy DOS in the OS. Apart from that, there are absolutely no issues. Heck, I've been able to play the original DOS game, prince of persia without any hitch whatsoever.
No one has posted to this discussion for at least three months. Please let old threads die and do not reply to them unless you feel you have something new and valuable to contribute that absolutely must be added to make the discussion complete. Otherwise, please start a new thread in this forum instead.