I usually put the OS on one drive, and user data on the other. That gives you the best split of performance, and reliability. IE, you can replace the system drive if it fails without losing your data. I do the same on Linux as well, so I can boot other operating systems, and still have access to all my user data.
rubberman
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Any HDD would be fine... It doesn't have to be running in the same hard disk for it to run normally. Usually when you install apps on other HDD other than HDD with OS, it would be still the same since it depends on your OS and computer specs.
If you have high capacity of free space in your first HDD, just install on same drive so when the second HDD is unavailable, you can still use Adobe plus more neatly (all install apps are install inside Program Files) but might installing apps on second HDD when first one do have little capacity to compensate for your apps. (create a folder to keep your apps organize)
I'm not sure which HDD you should stay away from aside from WD, Samsung, Maxtor and some HDD which I'm familiar with. If you're paranoid about it, just choose well-known brand and it should be enough...
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