What OS do you have? Since you said it's new, I'll assume it's XP.
There are two ways to do this:
The most common is to reboot your computer and then repeatedly hit F8 while it's booting up.
The other way to to go to Start, Run, type in msconfig, and click OK. When the System Configuration Utility window comes up, click the BOOT.INI tab, select SAFEBOOT, and then OK. You will get asked to reboot and when you do, it will come up in Safe Mode.
When you're done in Safe Mode, go back to msconfig and remove the checkmark from SAFEMODE.
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Posting Maven
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since Jul 2004