Try and update your drivers in your device manager
Go to your "system properties" and click on "hardware tab" then "device manager" look for "mice and other pointing devices"
Click on that device and you should see the device that you use for your mouse for example (PS/2 compatible mouse) click on the tab "drivers" you should see "update drivers" that should help.
If not you might have to reinstall the device.
also one other thing you could have a device conflict problem.