changed limits max_open_files warning in server

Hi,

we are running mysql 5.0.16-nt in windows 2003 server... we are getting frequently some warnings in the event viewer like
"Changed limits: max_open_files: 2048 max_connections: 450 table_cache: 794"
Once this warning arise, then the site has broken indicating "too many connections"..

I have gone through many of the threads posted in the net but I cant come to a solution and how to fix this problem..

Can you anybody give me suggestion for fix this problem?

Thanks