If you use wxPython for a GUI toolkit, you can get Boa Constructor. A Delphi like visual interface to do drag and drop frame building.
Free downlod from:
http://sourceforge.net/project/showfiles.php?group_id=1909&release_id=150280
The installer for Windows:
http://downloads.sourceforge.net/boa-constructor/boa-constructor-0.4.4.win32.exe
There is also a forum:
http://sourceforge.net/forum/forum.php?thread_id=1617033&forum_id=5483
Boa Constructor needs wxPython. It actually makes a great general IDE for all Python programming.
Microsoft does not like Python, they have meddled a little with IronPython (a pot of dung IMHO), but don't expect any support from them. I think in their narrow mindset they associate Python with Google.
The closest thing SharpDevelop will work with is the python-like Boo language that uses C# to compile.