Hi.
You can try this method. "FileUpload1" is server-control.
Good luck
Protected Sub cmdOK_Click(ByVal sender As Object, ByVal e As System.EventArgs) Handles cmdOK.Click
Dim _fileName As String = Request.PhysicalApplicationPath & FileUpload1.FileName
Dim _byte() As Byte = FileUpload1.FileBytes()
Dim _file As New IO.FileStream(_fileName, IO.FileMode.Create)
For _i As Integer = 0 To _byte.Length - 1
_file.WriteByte(_byte(_i))
Next
_file.Close()
'-----------------------
' DO SOMETHING
End Sub