try to modify your code like:
If ComboBox1.Text = "Lastname, Firstname" Then
If RadioBtn1.Checked = True Then
Process.Start("C:\Employee Records\City\State1\Lastname, Firstname\2008")
ElseIf RadioBtn2.Checked = True Then
Process.Start("C:\Employee Records\City\State2\Lastname, Firstname\2008")
Else
End If
ElseIf ComboBox1.Text = "Lastname2, Firstname" Then
If RadioBtn1.Checked = True Then
Process.Start("C:\Employee Records\City\State1\Lastname2, Firstname\2008")
ElseIf RadioBtn2.Checked = True Then
Process.Start("C:\Employee Records\City\State2\Lastname2, Firstname\2008")
Else
End If
End If