Your best option is always to use the built in import/export functionality that already exists and nearly all database systems. If for some odd reason this is not an option for you, you can connect to an Excel spreadsheet and read the rows of data just like you would any other database. Your DSN-less conenction string would be similar to :
"Driver={Microsoft Excel Driver (*.xls)};DriverId=790;Dbq=" & Server.mappath("./YourSheet.xls") & ";UID=admin;"
Just loop through the recordset, grab the values, then insert them into another db.