I would recommend, at a minimum, having the following tables:
Issue: ID
Client: ID, Name, etc
Ad: ID, Issue Id, Client ID, Date Booked, Price, etc
You would not have each issue as a separate table, but rather each issue would be a different record in the Issue table. You then track which Ads each client has booked by using the Ad table to track the client and which issue they have an ad booked in.
Some additional tables that may be helpful:
Client Phone Contact Names: ID, Client ID, Contact Name, Notes
Client Phone Number: ID, Client ID, Phone Number
Client Phone Address: ID, Client ID, Street Address, City, State, Zip
You can also track phone number, address, etc for each Contact as well. The database can certainly be more fine tuned, but I'd need more information about the ads and booking process to help further.