Send Focus out of DataGridView

Handle the DataGridView1.EditingControlShowing event,

Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load
        Dim dt As New DataTable
        dt.Columns.Add("No")
        dt.Columns.Add("Name")
        dt.Rows.Add(1, "A")
        dt.Rows.Add(2, "B")
        dt.Rows.Add(3, "C")
        DataGridView1.DataSource = dt

        AddHandler DataGridView1.EditingControlShowing, AddressOf MyEditHandler
End Sub

and from within the handler of EditingControlShowing, handles KeyUp event,

Sub MyEditHandler(ByVal s As Object, ByVal e As DataGridViewEditingControlShowingEventArgs)
        AddHandler e.Control.KeyUp, AddressOf MyKeyUpHandler
End Sub

Sub MyKeyUpHandler(ByVal s As Object, ByVal e As KeyEventArgs)
        If e.KeyCode = Keys.Enter Then
            TextBox1.Focus()
        End If
End Sub

Sir,

May you did not read the question carefully.

how is about this

While entering data, if sno column is empty and user press Enter or Tab then Focus must go to me.textbox1

You wrote:

Sub MyKeyUpHandler(ByVal s As Object, ByVal e As KeyEventArgs)        If e.KeyCode = Keys.Enter Then            TextBox1.Focus()        End IfEnd SubSub MyKeyUpHandler(ByVal s As Object, ByVal e As KeyEventArgs)
        If e.KeyCode = Keys.Enter Then
            TextBox1.Focus()
        End If
End Sub

How to know that sno columns is empty?

Add the handler for e.Control.Leave event and use CurrentCell.Value property of DataGridView to check the status.