Please see all the details from hijackthis:

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Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 14:59:24, on 19/05/2009
Platform: Windows XP SP3 (WinNT 5.01.2600)
MSIE: Internet Explorer v7.00 (7.00.6000.16762)
Boot mode: Normal

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\Program Files\Symantec\Symantec Endpoint Protection\Smc.exe
C:\Program Files\Common Files\Symantec Shared\ccSvcHst.exe
C:\WINDOWS\system32\spoolsv.exe
C:\Centenn.ial\Audit\CAgent32.exe
C:\Centenn.ial\Audit\xferwan.exe
C:\Program Files\Java\jre6\bin\jqs.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\Program Files\Symantec\Symantec Endpoint Protection\Rtvscan.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Symantec\Symantec Endpoint Protection\SmcGui.exe
C:\WINDOWS\SOUNDMAN.EXE
C:\Program Files\QuickTime\qttask.exe
C:\Program Files\Common Files\Symantec Shared\ccApp.exe
C:\Program Files\HP\HP Software Update\HPWuSchd2.exe
C:\Program Files\Java\jre6\bin\jusched.exe
C:\WINDOWS\system32\ctfmon.exe
C:\WINDOWS\system32\wuauclt.exe
C:\Program Files\Microsoft Office\OFFICE11\WINWORD.EXE
L:\mbl\workflow\workflow.exe
C:\Program Files\Microsoft Office\OFFICE11\EXCEL.EXE
C:\PROGRA~1\MICROS~2\OFFICE11\OUTLOOK.EXE
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://Lisnet
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://lisnet/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://lisnet/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKCU\Software\Microsoft\Internet Connection Wizard,ShellNext = http://lisnet/
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Window Title = Windows Internet Explorer provided by Lisney
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyServer = 10.36.30.249:8080
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyOverride = lisnet;<local>
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelper.dll
O2 - BHO: Java(tm) Plug-In SSV Helper - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre6\bin\ssv.dll
O2 - BHO: Java(tm) Plug-In 2 SSV Helper - {DBC80044-A445-435b-BC74-9C25C1C588A9} - C:\Program Files\Java\jre6\bin\jp2ssv.dll
O2 - BHO: JQSIEStartDetectorImpl - {E7E6F031-17CE-4C07-BC86-EABFE594F69C} - C:\Program Files\Java\jre6\lib\deploy\jqs\ie\jqs_plugin.dll
O4 - HKLM\..\Run: [SoundMan] SOUNDMAN.EXE
O4 - HKLM\..\Run: [SiSUSBRG] C:\WINDOWS\SiSUSBrg.exe
O4 - HKLM\..\Run: [SiSPower] Rundll32.exe SiSPower.dll,ModeAgent
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [Adobe Reader Speed Launcher] "C:\Program Files\Adobe\Reader 8.0\Reader\Reader_sl.exe"
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [HP Software Update] C:\Program Files\HP\HP Software Update\HPWuSchd2.exe
O4 - HKLM\..\Run: [SunJavaUpdateSched] "C:\Program Files\Java\jre6\bin\jusched.exe"
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKUS\S-1-5-18\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'SYSTEM')
O4 - HKUS\S-1-5-18\..\RunOnce: [TSClientMSIUninstaller] cmd.exe /C "cscript %systemroot%\Installer\TSClientMsiTrans\tscuinst.vbs" (User 'SYSTEM')
O4 - HKUS\.DEFAULT\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'Default user')
O4 - HKUS\.DEFAULT\..\RunOnce: [TSClientMSIUninstaller] cmd.exe /C "cscript %systemroot%\Installer\TSClientMsiTrans\tscuinst.vbs" (User 'Default user')
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\OFFICE11\EXCEL.EXE/3000
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\OFFICE11\REFIEBAR.DLL
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O15 - Trusted Zone: *.lisnet
O15 - Trusted Zone: http://*.lisnet
O15 - Trusted Zone: http://www.mortgagecrmlite.com
O15 - Trusted IP range: 10.36.30.1
O15 - Trusted IP range: http://10.36.30.1
O15 - Trusted IP range: 10.36.30.2
O15 - Trusted IP range: 10.36.30.3
O15 - Trusted IP range: 10.36.30.4
O15 - Trusted IP range: 10.36.30.254
O15 - Trusted IP range: 10.36.30.7
O15 - Trusted IP range: 10.36.30.1 (HKLM)
O15 - Trusted IP range: 10.36.30.2 (HKLM)
O15 - Trusted IP range: 10.36.30.3 (HKLM)
O15 - Trusted IP range: 10.36.30.4 (HKLM)
O15 - Trusted IP range: 10.36.30.254 (HKLM)
O15 - Trusted IP range: 10.36.30.7 (HKLM)
O16 - DPF: {02BF25D5-8C17-4B23-BC80-D3488ABDDC6B} (QuickTime Object) - http://a1540.g.akamai.net/7/1540/52/20070501/qtinstall.info.apple.com/qtactivex/qtplugin.cab
O16 - DPF: {62789780-B744-11D0-986B-00609731A21D} (Autodesk MapGuide ActiveX Control) - http://webgis.kildarecoco.ie/MapControl/Download/mgaxctrl.cab
O16 - DPF: {6E32070A-766D-4EE6-879C-DC1FA91D2FC3} (MUWebControl Class) - http://update.microsoft.com/microsoftupdate/v6/V5Controls/en/x86/client/muweb_site.cab?1149163160930
O16 - DPF: {6F15128C-E66A-490C-B848-5000B5ABEEAC} (HP Download Manager) - https://h20436.www2.hp.com/ediags/dex/secure/HPDEXAXO.cab
O16 - DPF: {73ECB3AA-4717-450C-A2AB-D00DAD9EE203} (GMNRev Class) - http://h20270.www2.hp.com/ediags/gmn2/install/HPProductDetection.cab
O16 - DPF: {A9F8D9EC-3D0A-4A60-BD82-FBD64BAD370D} (DDRevision Class) - http://h20264.www2.hp.com/ediags/dd/install/HPDriverDiagnosticsxp2k.cab
O16 - DPF: {E06E2E99-0AA1-11D4-ABA6-0060082AA75C} (GpcContainer Class) - https://brokercrm.webex.com/client/T26L/support/ieatgpc.cab
O16 - DPF: {EDFCB7CB-942C-4822-AF14-F0B687409848} (Image Uploader Control) - http://www.carzone.ie/my/aurigma/ImageUploader4.cab
O16 - DPF: {F5D98C43-DB16-11CF-8ECA-0000C0FD59C7} (ActiveCGM Control) - file://\\Lisnet\Applications\CGM Plugin (to view Dublin City maps)\Acgm.cab
O17 - HKLM\System\CCS\Services\Tcpip\Parameters: Domain = lisney.com
O17 - HKLM\Software\..\Telephony: DomainName = lisney.com
O17 - HKLM\System\CS1\Services\Tcpip\Parameters: Domain = lisney.com
O17 - HKLM\System\CS2\Services\Tcpip\Parameters: Domain = lisney.com
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccSvcHst.exe
O23 - Service: Symantec Settings Manager (ccSetMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccSvcHst.exe
O23 - Service: CentennialClientAgent - Centennial UK Ltd. - C:\Centenn.ial\Audit\CAgent32.exe
O23 - Service: CentennialIPTransferAgent - Centennial UK Ltd. - C:\Centenn.ial\Audit\xferwan.exe
O23 - Service: InstallDriver Table Manager (IDriverT) - Macrovision Corporation - C:\Program Files\Common Files\InstallShield\Driver\1050\Intel 32\IDriverT.exe
O23 - Service: Java Quick Starter (JavaQuickStarterService) - Sun Microsystems, Inc. - C:\Program Files\Java\jre6\bin\jqs.exe
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: Symantec Auto-upgrade Agent (Smcinst) - Unknown owner - C:\Program Files\Symantec\Symantec Endpoint Protection\SmcLU\Setup\smcinst.exe (file missing)
O23 - Service: Symantec Management Client (SmcService) - Symantec Corporation - C:\Program Files\Symantec\Symantec Endpoint Protection\Smc.exe
O23 - Service: Symantec Network Access Control (SNAC) - Symantec Corporation - C:\Program Files\Symantec\Symantec Endpoint Protection\SNAC.EXE
O23 - Service: Symantec Endpoint Protection (Symantec AntiVirus) - Symantec Corporation - C:\Program Files\Symantec\Symantec Endpoint Protection\Rtvscan.exe

--
End of file - 8599 bytes

Just posting the log, while it may reveal "something" tells us nothing about what problems you are having and WHEN? We need more than just

Please see all the details from hijackthis:

We don't KNOW the other necessary details unless you tell us.

Thanks jholland1964,

Well the PC is very slow. Especially when running Outlook or word or any other application.

My initial thought was the Symantec anti-virus software Symantec Endpoint Protection 11.0 then I removed for while and the issue continued PC still slow.

As you can see from the log file there’s nothing that is out of normal application.

I hope this helps if you cant help is fine two.

Couple of questions here, did you personally add all those addresses to Trusted Sites? Is your ISP lisney.com? Have you done a general clean up....temp files, cookies, etc? Have you done a disk defrag lately? Is the computer only slow when online or all the time?

Couple of questions here, did you personally add all those addresses to Trusted Sites? Is your ISP lisney.com? Have you done a general clean up....temp files, cookies, etc? Have you done a disk defrag lately? Is the computer only slow when online or all the time?

Thanks mate this seemes to done the trick

''I just done a disk defrag''

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