It really doesn't matter. You can run one desktop, and still run applications built for others, such as KDE apps on Gnome, Gnome apps of XFCE, etc. You can try most of the with live CD/DVD distributions without installing them, to find one that you are most comfortable with. I have used Motif, KDE, Gnome, TWM, XFCE, and others though currently I am running Gnome (with a bunch of KDE applications as well) on Scientific Linux 6 (a clone of Red Hat Enterprise Linux 6) that I am pretty happy with. You will always have issues - nothing is perfect. That's why I suggest you try a bunch of live DVD's to see what you like best. Burn the appropriate ISO images to a DVD-RW so you can reuse it with different distributions as you go.
rubberman
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Well, I personally think that Ubuntu peaked at 9.04 and has gone downhill since... :-) Right now I am using Scientific Linux 6 (a clone of RHEL 6 supported by Fermi National Laboratory and CERN) and will be testing 6.1 soon. I have a few (very few) quibbles with it, but for the most part I have been happy using it, and it supports a lot of hardware that older versions of RHEL/CentOS/SL did not. Bear in mind that over the past number of years I have used (actively) Gentoo, Ubuntu, Fedora, RHEL (SL, CentOS), Suse, Debian, Mepis, and other distributions of Linux. None are perfect, but they all share one characteristic - you can tailor/tune all of them to behave as you want. That is not to say it doesn't take some time/work/effort to accomplish that, but it is certainly possible to do so.
rubberman
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