import wx
import os
from wxPython.wx import *
import wx.html

class MyHtmlFrame(wx.Frame):

    def __init__(self, parent, title):

        wx.Frame.__init__(self, parent, -1, title)

        html = wx.html.HtmlWindow(self)
        html.SetPage(
            "This is test implementation of Simple <b>Notepad</b> using <font color=\"red\">wxPython</font> !!!! "
            "<br>View is created using <font color=\"red\">wxGlade</font>")

class MyFrame(wx.Frame):
    def __init__(self, *args, **kwds):
        # begin wxGlade: MyFrame.__init__
        kwds["style"] = wx.DEFAULT_FRAME_STYLE
        wx.Frame.__init__(self, *args, **kwds)
        #wx.Frame.__init__(self, parent, -1, title, pos=(150, 150), size=(350, 250))

        self.flag = 0
        # Menu Bar
        self.frame_1_menubar = wx.MenuBar()

        self.SetMenuBar(self.frame_1_menubar)
        self.File = wx.Menu()
        self.New = wx.MenuItem(self.File, wx.NewId(), "&New", "", wx.ITEM_NORMAL)
        self.File.AppendItem(self.New)        
        self.Save = wx.MenuItem(self.File, wx.NewId(), "Save &As", "", wx.ITEM_NORMAL)
        self.File.AppendItem(self.Save)
        self.open = wx.MenuItem(self.File, wx.NewId(), "&Open", "", wx.ITEM_NORMAL)
        self.File.AppendItem(self.open)
        self.About = wx.MenuItem(self.File, wx.NewId(), "A&bout", "", wx.ITEM_NORMAL)
        self.File.AppendItem(self.About)        
        self.Exit = wx.MenuItem(self.File, wx.NewId(), "&Exit", "", wx.ITEM_NORMAL)
        self.File.AppendItem(self.Exit)
        self.frame_1_menubar.Append(self.File, "&File")
        # Menu Bar end

        # Tool Bar

        #self.frame_1_toolbar = wx.ToolBar(self, -1, style=wx.TB_HORIZONTAL|wx.TB_FLAT|wx.TB_DOCKABLE|wx.TB_3DBUTTONS|wx.TB_TEXT|wx.TB_NOICONS|wx.TB_NODIVIDER|wx.TB_NOALIGN|wx.TB_HORZ_LAYOUT|wx.TB_HORZ_TEXT)
        #self.SetToolBar(self.frame_1_toolbar)

        # Tool Bar end

        self.frame_1_statusbar = self.CreateStatusBar(1, 0)


        self.__set_properties()
        self.__do_layout()
        self.SetStatusText("Notepad using wxPython")            
        self.Bind(wx.EVT_MENU, self.file_save, self.Save)
        self.Bind(wx.EVT_MENU, self.open_file, self.open)
        self.Bind(wx.EVT_MENU, self.file_new, self.New)
        self.Bind(wx.EVT_MENU, self.file_exit, self.Exit)
        self.Bind(wx.EVT_MENU, self.about, self.About)

        # end wxGlade

    def __set_properties(self):
        # begin wxGlade: MyFrame.__set_properties
        self.SetTitle("Simple Notepad using wxPython")
        #self.frame_1_toolbar.SetToolBitmapSize((0, 0))
        #self.frame_1_toolbar.Realize()
        self.frame_1_statusbar.SetStatusWidths([-1])
        # statusbar fields
        frame_1_statusbar_fields = ["frame_1_statusbar"]
        for i in range(len(frame_1_statusbar_fields)):
            self.frame_1_statusbar.SetStatusText(frame_1_statusbar_fields[i], i)
        # end wxGlade

    def __do_layout(self):
        # begin wxGlade: MyFrame.__do_layout
        sizer_1 = wx.BoxSizer(wx.VERTICAL)
        self.SetAutoLayout(True)
        self.SetSizer(sizer_1)
        sizer_1.Fit(self)
        sizer_1.SetSizeHints(self)
        self.Layout()
        # end wxGlade

    def file_save(self, event): # wxGlade: MyFrame.<event_handler>
        if self.flag == 1 :
            dialog = wxFileDialog ( None, style = wxSAVE )
            # Show the dialog and get user input
            if dialog.ShowModal() == wxID_OK:
                file_path = dialog.GetPath()
                file = open(file_path,'w')
                file_content = self.text_ctrl_1.GetValue()
                file.write(file_content)
            else:
                print 'Nothing was selected.'
            # Destroy the dialog
            self.SetStatusText("Your file has been saved")        
            dialog.Destroy()
        else:
            dlg = wxMessageDialog(self, "plz open a new file !!!!",
                              "New File", wxOK | wxICON_INFORMATION)
            dlg.ShowModal()
            dlg.Destroy()            

    def open_file(self, event): # wxGlade: MyFrame.<event_handler>
        if self.flag ==1:
            filters = 'Text files (*.txt)|*.txt'
            dialog = wxFileDialog ( None, message = 'Open something....', wildcard = filters, style = wxOPEN | wxMULTIPLE )
            if dialog.ShowModal() == wxID_OK:
                filename = dialog.GetPath()
                file = open(filename,'r')
                file_content = file.read()
                self.text_ctrl_1.SetValue(file_content)
            else:
                print 'Nothing was selected.'
            dialog.Destroy()
        else:
            dlg = wxMessageDialog(self, "plz open a new file !!!!",
                              "New File", wxOK | wxICON_INFORMATION)
            dlg.ShowModal()

        # Destroy the dialog
        self.SetStatusText("Your file is opened")
        dlg.Destroy()

    def file_new(self, event): # wxGlade: MyFrame.<event_handler>
        self.flag = 1
        sizer_1 = wx.BoxSizer(wx.VERTICAL)
        self.text_ctrl_1 = wx.TextCtrl(self, wx.ID_ANY, style=wx.TE_MULTILINE| wx.SUNKEN_BORDER)
        sizer_1.Add(self.text_ctrl_1, 0, wx.ALL|wx.EXPAND|wx.ALIGN_RIGHT|wx.ADJUST_MINSIZE, 0)
        self.text_ctrl_1.SetMinSize((500, 500))
        self.SetAutoLayout(True)
        self.SetSizer(sizer_1)
        sizer_1.Fit(self)
        sizer_1.SetSizeHints(self)
        self.Layout()        
        self.text_ctrl_1.SetFocus()        

    def file_exit(self, event): # wxGlade: MyFrame.<event_handler>
        """Bring up a wx.MessageDialog with a quit message."""
        alert = wx.MessageDialog(self, "Do you really want to quit")
        response = alert.ShowModal()
        alert.Destroy()

        if response == wx.ID_OK:
            print "The user clicked the 'OK' button."
            self.Close()            
        else:
            print "The user clicked the 'Cancel' button."
            event.Skip()   
    def about(self,event):
        frm = MyHtmlFrame(None, "About ....")
        frm.Show()

        #dlg = wxMessageDialog(self, "This is test implementation of Simple Notepad using wxPython !!!!",
        #                      "New File", wxOK | wxICON_INFORMATION)
        #dlg.ShowModal()
        #dlg.Destroy()

# end of class MyFrame


class MyNotepad(wx.App):
    def OnInit(self):
        wx.InitAllImageHandlers()
        frame_1 = MyFrame(None, -1,"Notepad")
        self.SetTopWindow(frame_1)
        frame_1.Show()
        return 1

# end of class MyNotepad

if __name__ == "__main__":
    app = MyNotepad(0)
    app.MainLoop()

One more time:

Code tags are particularly important with Python code since they preserve the indentations. Without the proper indentations Python code becomes hard to read and understand!

I will show the needed tags in reverse so they don't activate:
at the end of your code add this tag /code
at the start of your code add tag code=Python

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