hello guys..

can you help me on how to make 45 angle shoot or 45 angle movement of bullet in vb.net

See if this helps.
1 Button, 1 PictureBox

Private Sub Button1_Click(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles Button1.Click
        With PictureBox1
            .Left += 5
            .Top += 5
        End With
    End Sub

To change direction of movement, use .Left -= 5 , etc..