Debug time Application run good all private sub and Function work properly, but with out debug not run properly please help me

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Can't do much without seeing your code.

Generally speaking, the difference between the debug and the releases build is that:
In a debug build the complete symbolic debug information is emitted to help while debugging applications and also the code optimization is not taken into account.
While in release build the symbolic debug info is not emitted and the code execution is optimized.
Also, because the symbolic info is not emitted in a release build, the size of the final executable is lesser than a debug executable.

You can try the following solutions:

  1.   If you try to create a new project, see whether this issue still exists. Sometimes corrupted project settings can cause problems.  And not caused by VS IDE.
  2. Try deleting the references to the libraries and re-adding them. Then rebuild under release mode.

See if the following related threads are helpful:

What related threads?

Dani, why this question?

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