Add this code any where in your main form and You will be able to disable the X button on a winForm

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private const int dis_close_button = 0x200;
 protected override CreateParams CreateParams
 {
     get
     {
        CreateParams ObjCP = base.CreateParams;
        ObjCP.ClassStyle = ObjCP.ClassStyle | dis_close_button ;
        return ObjCP;
     }
 }
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