I previously used 32bit Python 2.7 on Windows Vista. My new PC is Windows8 and 64 bit.

I would like Python to work with Microsoft Office Excel.

Is the best / simplest way forward to stick with 32 bit Python and 32 bit Excel?
Can you mix 32 bit Python and 64 bit Excel?

The 64 bit Python version does not work with 32 bit third party modules.

I know but that is not my query.

Can you mix 32 bit Python and 64 bit Excel?
Give it a try.

If you are using a third party module to interface with Excel, make sure its available in 64 bit format.
I am thinking of xlrd or xlwt which are still 32 bits.