You question is a bit too vague, I think, to know what help we might provide. Have you looked over the docs of the jira-python project at http://jira-python.readthedocs.org/en/latest/? There is an examples section that shows how to exercise the jira-python library that may give you some idea of where to start.
If you have some sample code or an error you are getting with your current code, we can have a look. Good luck!