i need to disable my combobox dropdown database values when another combobox value is clicked ...any help plss ...

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Do it in ComboBox_SelectionChanged Event.

If you select an Item from ComboBox1 DropDown List Then
ComboBox2.Enabled = False

Shark_1 i need only combobox dropdown not enabled when click an combobox1 dropdown

What do you mean by "i need only combobox dropdown not enabled"?
What do you want? Do you mean to clear the combobox items?

Describe your problem.

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