I have just ran it last weekend with hesitancy being every time I try one of these registry programs, they seem to cause more harm than good and it has bricked the HD. I usually try one twice a year and have the same problem. Please note - I'm not saying that this isnt a good program as others have posted great results in other posts, but for me, I don't seem to have the greatest luck and still have the best results reformatting every 6 months for a fresh start.
At this point, I'm trying to find a way to load RegistryEasy from the command prompt (at boot-up being windows cannot load) with attempts to restore the back-up registry file.