I would like to make an Online Course Application System. I'm just wondering, what are the frameworks,technology that I need to get started? I'm thinking of using PHP and MySQL. I've used Joomla before, but for normal web page, is Joomla capable of handling such system? Thanks.

PHP/MySql & Joomla are capable of pretty much anything.
Could you expand on "Online Course Application System" ? I'm trying to figure out exactly what you need.